Premium grade cholic acid series, manufactured under strict global regulatory and chemical compliance standards.
Bile acids are a group of steroid acids synthesized primarily in the liver of vertebrates. They are derived from cholesterol through a highly complex multienzymatic pathway. The cholic acid series, containing molecules such as Cholic Acid (CA), Chenodeoxycholic Acid (CDCA), Ursodeoxycholic Acid (UDCA), Deoxycholic Acid (DCA), and their respective conjugated forms (such as sodium salts or taurine/glycine conjugates like TUDCA), represents one of the most critical classes of biochemical molecules in human physiology and therapeutic medicine.
Bile acids exhibit amphipathic structures containing a hydrophilic face (alpha-hydroxyl groups) and a hydrophobic face (beta-methyl groups). This unique configuration facilitates the emulsification of dietary lipids, aiding pancreatic lipase action in the gut. Beyond digestive functions, they act as powerful signaling ligands, interacting with the Farnesoid X Receptor (FXR) and the G-protein coupled bile acid receptor 5 (TGR5) to regulate metabolic homeostasis, lipid clearance, and inflammatory responses.
For pharmaceutical manufacturers, sourcing high-purity cholic acid derivatives is paramount. The synthesis or natural extraction of these compounds requires extreme precision. Even minor deviations in purity profiles, isomer ratios, or heavy metal contamination can disrupt the therapeutic action or fail stringent regulatory reviews. As a premier manufacturer, Chengdu Chenlv Herb Co., Ltd. focuses on maintaining absolute structural homogeneity and chemical purity in every batch.
Your Trusted Global Partner in Botanical & Natural Biochemical Ingredients
Chengdu ChenLv Herb Co.,Ltd. (referred to as "Chenlv Herb") was established in 2012 as a high-tech enterprise specializing in the R&D, production, and sales of botanical extracts and natural pharmaceutical ingredients. Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, food, and cosmetics.
Operating from our state-of-the-art facility, we leverage advanced synthetic biology and eco-friendly chemical isolation techniques. Our mission is to bridge the gap between traditional extraction methods and cutting-edge pharmaceutical requirements, ensuring a stable, traceable, and highly reliable supply chain for global distributors.
The global demand for cholic acid series products has experienced an unprecedented upward trajectory over the past decade. Industry experts project this market expansion to accelerate due to rising incidences of lifestyle-related metabolic disorders (such as metabolic dysfunction-associated steatohepatitis/MASH) and the rapid growth of the biopharmaceutical sector. The commercialization of bile acids is no longer confined to traditional digestive enzyme supplements; it has transitioned into targeted therapeutics, cosmetic fat-dissolution formulations, and diagnostic reagent components.
In North America and Europe, stringent regulatory policies mandated by the FDA and EMA require bile-derived products to prove complete freedom from transmissible spongiform encephalopathies (TSE/BSE). This regulatory push has redirected global procurement strategies. Companies are shifting their focus to verified manufacturers that utilize semi-synthetic techniques or source raw materials from controlled, certified agricultural lines. The requirement for CE, ISO, and KOSHER certifications is standard in modern commercial transactions.
To mitigate the risk of animal-derived pathogens, manufacturers are investing heavily in biosynthesis. Through engineered yeast and bacterial hosts, companies can synthesize the steroid ring of cholic acids without relying on bovine or porcine bile collection. However, during this transition, high-purity natural extraction coupled with advanced purification technologies remains the most cost-effective and chemically viable route for global developers.
Concurrently, emerging markets in Asia-Pacific and Latin America are expanding their localized pharmaceutical manufacturing footprint, leading to increased localized application scenarios. For instance, in China and India, local pharmaceutical firms are scaling up the production of generic UDCA formulations, driving local demand for high-purity Cholic Acid as a key starting material (KSM).
Why Leading Pharmaceutical & Health Brands Partner with Chenlv Herb
Creative molecular designs and optimization processes that elevate your brand and improve active pharmaceutical ingredient bioavailability.
Streamlined chemical processing and automated extraction cycles designed to maximize yield and speed up delivery timelines.
End-to-end green extraction and eco-friendly manufacturing waste management systems, aligned with contemporary global ESG standards.
Fast global support and responsive engineering consulting to facilitate seamless customized chemical configurations.
Comprehensive analytics testing, including HPLC, GC, LC-MS, and heavy metal tracking, ensuring strict compliance with pharmacopoeia standards.
Over 28 years of industry-leading production experience in natural chemical synthesis and biological ingredient manufacturing.
The global pharmaceutical supply chain has faced historic supply-side constraints. Against this backdrop, China’s chemical manufacturing sector has undergone a massive structural shift, integrating advanced automation and data analytics. This shift is referred to as China Factory 4.0. Chengdu Chenlv Herb Co., Ltd. is a prime example of this industrial transformation.
By utilizing automated process control systems (PCS) and supervisory control and data acquisition (SCADA) platforms, our 9,514㎡ manufacturing facility monitors key extraction parameters—such as temperature, pressure, solvent ratio, and crystallization speed—in real time. This automated oversight minimizes batch-to-batch variation, ensuring a level of chemical consistency that manual setups cannot achieve.
Under tight domestic environmental policies, Chenlv Herb operates a closed-loop solvent recycling system. Over 95% of extraction solvents are recaptured and distilled for reuse, significantly reducing production costs and eliminating volatile organic compound (VOC) emissions. This integration of green chemistry helps stabilize global export pricing against raw material market volatility.
For international buyers, this operational model provides a dual benefit: price stability and supply chain security. Our direct access to raw agricultural collection points, combined with our automated refining capabilities, allows us to maintain a constant supply of bile acids and derivatives. This continuous production is maintained regardless of seasonal changes or raw material market fluctuations, offering a reliable alternative to unstable supply chains.
How the Cholic Acid Series Operates Across Key Global Markets
Driven by the concept of "homology of medicine and food" and modern health needs, plant extracts and bile acids have become core raw materials due to their natural, green, and safe characteristics.
From herbal formulas recorded in ancient books to modern innovative drugs, plant extracts and pure synthetic bile acids occupy a prominent position in the pharmaceutical industry due to their natural active ingredients.
With consumers' pursuit of natural, safe, and sustainable skincare concepts, plant extracts have become a new favorite in the cosmetics industry due to their mildness, versatility, and biocompatibility.
Plant extracts and bile salts show great potential in improving animal health, enhancing production performance, and optimizing culture benefits, and are becoming a research hotspot in animal nutrition.
For biochemical raw materials, quality assurance requires verifiable chemical metrics. Below is an overview of the key quality standards followed during the production of our high-purity Cholic Acid Series.
| Compound Name | Assay (HPLC) | Loss on Drying | Heavy Metals | Pathogen Status |
|---|---|---|---|---|
| Cholic Acid (CA) | ≥ 98.0% / 99.0% | ≤ 0.5% | ≤ 10 ppm | Negative / BSE-TSE Free |
| Chenodeoxycholic Acid (CDCA) | ≥ 99.0% | ≤ 1.0% | ≤ 10 ppm | Negative / Pyrogen Free |
| Ursodeoxycholic Acid (UDCA) | ≥ 99.0% - 101.0% (EP/USP) | ≤ 0.5% | ≤ 5 ppm | Negative / Endotoxin Controlled |
| Sodium Deoxycholate | ≥ 98.5% | ≤ 2.0% | ≤ 10 ppm | Negative / Culture Grade ready |
To verify these parameters, our QA laboratory uses high-performance liquid chromatography (HPLC) with refractive index (RI) detection or evaporative light scattering detection (ELSD). This setup is necessary because bile acids lack strong ultraviolet chromophores. We verify structural identity using nuclear magnetic resonance (1H-NMR) and Fourier-transform infrared spectroscopy (FT-IR), providing customers with reliable product documentation.
How Chenlv Herb Executes Tailored OEM / ODM Chemical Configurations
Define molecular parameters, assay, and target applications.
Provide pricing and manufacturing timelines.
Establish legal and quality agreements (QAs).
Synthesize and ship pilot batch samples for testing.
Initiate mass production in our automated facility.
Perform analytical verification and issue COA.
Ship materials globally with temperature tracking.
Complying with International Standards for Quality and Safety
Insights from Our Technical and Scientific Research Team
Stay informed on market trends, raw material pricing, and biotechnological developments
Recently, the market price of Citrus aurantium raw materials in China has been on the rise, drawing significant attention from the industry. As the new production season comes to an end, price fluctuations remain a focal point.
As a leading platform for China's pharmaceutical industry on the global stage, the 23rd CPHI China 2025 joins hands with the 18th PMEC China to showcase advanced production technologies.
The 92nd China International Pharmaceutical Raw Materials/Intermediates Exhibition (API China) will open in Guangzhou, highlighting new biological technologies and advanced ingredients.
High-purity secondary bile acids, sodium salts, and conjugates for advanced pharmaceutical research and development.
Chenlv Herb
