Berberine Sulfate (CAS: 316-41-6) is an isoquinoline alkaloid sulfate extracted from medicinal plants such as Berberis aristata and Phellodendron amurense. This compound exhibits remarkable antibacterial (particularly against enteropathogens), anti-inflammatory, and glucose/lipid-modulating effects, with its hypoglycemic mechanism primarily involving AMPK pathway activation to improve insulin resistance. Clinically, it is widely used for bacterial diarrhea, adjunctive therapy for type 2 diabetes, and metabolic syndrome management, with a recommended daily dose of 300-500mg. Modern formulation technologies (e.g., nanocrystals or phospholipid complexes) can significantly enhance its oral bioavailability (from <5% to over 20%).